A new Virtual Museum Exhibition Designer using an Enhanced ARCO Standard (ViMEDEAS) framework has been developed to support curators and visitors. It unifies features of a recently presented curator tool that allows exhibition planning and includes a functionality for editing existing exhibition layouts and visitors' museum tours and the Replicave2 framework that generates a Web-based virtual 3D museum defined by various parameters at runtime. The framework uses the Virtual Museum and Cultural Object Exchange Format (VIMCOX), which includes new features such as room design and interactions with exhibits. VIMCOX is sufficiently flexible to gather the administrative, descriptive, technical and use metadata in a way that enables users to search the desired information and to create, display and manipulate virtual instances of artwork and whole exhibitions in a simple and intuitive way.