After two successful versions of the Workshop on Collaborative Technologies and Data Science in Smart City Applications (CODASSCA 2018 and 2020) we are glad to present proceedings of the third version held at the American University of Armenia (AUA), August 23-25, 2022 in Yerevan, Armenia. This book presents 15 selected and carefully revised papers, which were originally made available at the start of the workshop in the Open Access Proceedings, also entitled Data Science, Human-Centered Computing, and Intelligent Technologies. Society, technology, and science are undergoing a rapid and revolutionary transformation towards incorporating Artificial Intelligence in every system humans use in everyday life for creating Smart Environments (SmE) through Ambient Intelligence (AmI) in highly interconnected and collaborative scenarios. The main source and asset for making smart systems is rich data, which is produced today in extraordinarily large quantities thanks to recent advances in sensors and sensor networks and is carefully processed for pervasive and embedded computing. Rich data enhances the capabilities of everyday objects and eases collaboration among people. Mobile systems could enhance the possibilities available for designers and practitioners. Effective analysis, quality assessment, and utilization of big data are key factors for success in many business and service domains, including smart systems. Major industrial domains are on the way to performing this tectonic shift based on Big Data, Artificial Intelligence, Collaborative Technologies, Smart Environments supporting Virtual and Mixed Reality Applications, Multimodal Interaction, and Reliable Visual and Cognitive Analytics. However, before we can effectively and efficiently turn the huge amount of generated data into information and knowledge, a number of requirements must be fulfilled and international standards for the quality of and access to the data developed and applied. The first requirement is to ensure that data quality--which includes the accuracy and integrity of the obtained data, timely delivery, suitable quantity, integrity, privacy and security requirements, and Digital Rights Management--complement realization and deployment of modern design, implementation, and evaluation tools. The second is to develop models, which can turn the data into valuable information and then into knowledge. Two important characteristics are desirable for regression and classification models: accuracy and interpretability. While accuracy deals with the ability of the model to predict a certain outcome, interpretability deals with the ability of the model to explain the reasons for producing a certain outcome. The aim of this workshop is to bring together researchers and practitioners working on both theoretical and practical aspects of data generation, data processing, and knowledge creation. These aspects include social issues that arise when using AI-powered systems in collaborative scenarios and smart cities applications.