Results: We present a highly compressed filesystem that specializes in storing large collections of genomes and reads. The system obtains orders-of-magnitude compression by using Relative Lempel-Ziv, which exploits the high similarities between genomes of the same species. The filesystem transparently stores the files in compressed form, intervening the system calls of the applications without the need to modify them. A client/server variant of the system stores the compressed files in a server, while the client's filesystem transparently retrieves and updates the data from the server. The data between client and server is also transferred in compressed form, which saves an order of magnitude network time.
Availability: The C++ source code of our implementation is available for download in https://github.com/vsepulve/relz_fs.